Alexander R. A. Anderson

A. R. A. Anderson is with the Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 USA.


Contributions

  • Stem Cell Plasticity and Niche Dynamics in Cancer Progression
    Stem Cell Plasticity and Niche Dynamics in Cancer Progression

    Cancer stem cells are believed to be the sole initiator and driver of tumor growth, given their self-renewal and tissue restoration properties. Their eradication may offer the ultimate in targeted tumor treatment. We challenge the strict hierarchical view of cancer stem cells and investigate the hypothesis of a plastic, niche-dependent stem phenotype, where the niche dictates the cell’s ability to maintain its stem-like state. We develop a two-dimensional hybrid discrete-continuum cellular automata model to describe the cell scale dynamics of multicellular tissue formation, and its environmental regulation.

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