Posts Tagged: Electrophysiology

  • High-Resolution Electrogastrogram: A Novel, Noninvasive Method for Determining Gastric Slow-Wave Direction and Speed

    High-Resolution Electrogastrogram: A Novel, Noninvasive Method for Determining Gastric Slow-Wave Direction and Speed

    Clinical tools to diagnose gastrointestinal (GI) disease are invasive or require radiation. Moreover, there is no widely established clinical technology analogous to the ECG for the “Functional” GI disorders are poorly understood, highly prevalent and have significant individual, health care, and socioeconomic consequences. The methodology we developed and described in this manuscript has the potential to change the diagnosis of GI disorders as well as inspire new therapies.

  • The Past, Present, and Future of Real-Time Control in Cellular Electrophysiology

    Jennifer A. Bauer, Katherine M. Lambert, and John A. White, Brain Institute, University of Utah
    Volume 61, Issue 5, Page:1448-1456
    For over 60 years, real-time control has been important for the study of excitable cells. Two such control-based technologies are reviewed here. Voltage-clamp methods revolutionized the study of excitable cells. In these techniques, membrane potential is controlled, allowing one to parameterize a powerful class of models that describe the voltage-current relationship of cell membranes. Dynamic-clamp methods allow the addition of new, ‘virtual’ membrane mechanisms to living cells. Dynamic clamp allows researchers unprecedented ways of testing computationally based hypotheses in biological preparations. Future improvements and uses of control-based technologies are also discussed.

  • Volume: 60, Issue: 7, Page(s): 2042-2051

    Minimizing Cytosol Dilution in Whole-Cell Patch-Clamp Experiments

    The cell is the basic unit of life. While living, it responds to diverse internal and external stimuli and exchanges materials across its plasma membrane through various types of pores and processes…

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