Posts Tagged: tissue engineering

  • 4-D Flow Control in Porous Scaffolds: Toward a Next Generation of Bioreactors

    4-D Flow Control in Porous Scaffolds: Toward a Next Generation of Bioreactors

    The article presents a novel methodology for spatiotemporal control of mechanical forces in scaffolds that enables generating on demand flow fields in real-time and can adapt to changes in the environment. This was achieved with a multi-inlet bioreactor and a control algorithm with learning capabilities. Non-invasive measurements of the scaffold’s hydrodynamic properties are obtained using nuclear magnetic resonance imaging and provide feedback for real-time control.

  • Towards a Portable Cancer Diagnostic Tool Using a Disposable MEMS-based Biochip

    A portable cancer diagnostic tool integrated with a disposable MEMS-based biochip is developed for measuring electro-thermo-mechanical (ETM) properties of the breast tissue. The ETM properties of the normal and cancerous breast tissues are measured by indenting the tissue placed on the biochip integrated inside the 3D printed tool.

  • Strategies for Whole Lung Tissue Engineering

    Elizabeth A. Calle, Mahboobe Ghaedi, Sumati Sundaram, Amogh Sivarapatna, Michelle K. Tseng, and Laura E. Niklason, Yale University, Volume 61, Issue 5, Page: 1482-1496
    Whole organ engineering has progressed rapidly in recent years. This is in large part due to the increased availability and use of decellularized whole lung organ scaffolds. This strategy is particularly advantageous for the lung, as it possesses a complex branching structure that is critical to its function of gas exchange. In addition to an appropriate scaffold that is sterile and hospitable to cell growth, epithelial, endothelial, and mesenchymal cells are required, as well as a bioreactor system in which to cultivate the organ. Here, we describe the successes and challenges in each of these areas of whole lung engineering.

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