Elizabeth A. Calle, Mahboobe Ghaedi, Sumati Sundaram, Amogh Sivarapatna, Michelle K. Tseng, and Laura E. Niklason, Yale University, Volume 61, Issue 5, Page: 1482-1496
Whole organ engineering has progressed rapidly in recent years. This is in large part due to the increased availability and use of decellularized whole lung organ scaffolds. This strategy is particularly advantageous for the lung, as it possesses a complex branching structure that is critical to its function of gas exchange. In addition to an appropriate scaffold that is sterile and hospitable to cell growth, epithelial, endothelial, and mesenchymal cells are required, as well as a bioreactor system in which to cultivate the organ. Here, we describe the successes and challenges in each of these areas of whole lung engineering.