Effect of Tissue Heterogeneity on the Transmembrane Potential of Type-1 Spiral Ganglion Neurons: A Simulation Study
Mathematical models of auditory nerve stimulation by cochlear implants play a prominent role to understand the underlying neural mechanisms. In spite of evidential heterogeneity, existing in silico models assumed a homogeneous medium in the Rosenthal’s canal to study the cochlear implant functionality…
Mechanical Imaging of Soft Tissues with a Highly Compliant Tactile Sensing Array
The mechanical imaging of lumps in tissues via surface measurements can permit the noninvasive detection of disease-related differences in body tissues. We developed a highly compliant mechanical imaging system for capturing tissue properties during automatic or human-guided palpation. We demonstrate that the system is able to image simulated tumors (lumps), yielding accurate estimates of cross section area independent of depth.
Novel Quantitative Analytical Approaches for Rotor Identification and Associated Implications for Mapping
Atrial fibrillation (AF) is the most common cardiac arrhythmia in humans, which is believed to be maintained by reentry sources (rotors). Identification of pivot points of rotors is important for performing AF treatment via catheter ablation. We developed several novel approaches that can accurately identify the pivot points of rotors, using different cardiac signal characteristics than currently existing techniques…
A Three-Dimensional Arrayed Microfluidic Blood–Brain Barrier Model With Integrated Electrical Sensor Array
A microfluidic multi-channel blood-brain-barrier (BBB) chip model with integrated electrical sensor array for label-free barrier function analysis has been successfully developed. The developed system includes features that closely mimic the in vivo structures of the BBB and a multitude of physiological functions.
Enhancement of Intercellular Electrical Synchronization by Conductive Materials in Cardiac Tissue Engineering
It is generally hypothesized that electroactive scaffolds would take effect by increasing cardiac synchronization. An equivalent-circuit model is developed to test this hypothesis. By sweeping critical model parameters, it is found that cardiac synchronization is most sensitive to the seal resistance, while surface roughness and conductivity of the material have less impact.
Spatial Position Measurement System for Surgical Navigation Using 3-D Image Marker-Based Tracking Tools With Compact Volume
We proposed a spatial position measurement system using 3-D image marker and tracking tools with both compact volume and high positional measurement accuracy for surgical navigation, especially in limited surgical environment in minimally invasive surgery.