Hao F. Zhang

Hao F. Zhang is with the Biomedical Engineering Department, Northwestern University, Evanston, IL 60201 USA.


  • In Vivo Super-resolution Imaging of Neuronal Structure in the Mouse Brain
    In Vivo Superresolution Imaging of Neuronal Structure in the Mouse Brain

    By synchronizing a resonance galvo scanner and electro-optic modulator, resonant two-photon Super-resolution Patterned Excitation Reconstruction (2P-SuPER) microscopy combines two-photon laser scanning microscopy (2P-LSM) with the super-resolution ability of structured illumination microscopy. This technique optimizes the combination of imaging resolution, speed, and depth for super-resolution investigations in the brains of living animals.

  • Optical Detection of Ultrasound in Photoacoustic Imaging
    Optical Detection of Ultrasound in Photoacoustic Imaging

    Photoacoustic (PA) imaging offers unique capabilities in studying biological tissue based on optical absorption contrast. The sensitivity and bandwidth in detecting laser-induced ultrasonic signals are crucial for attaining high-quality and high-resolution PA images. Recent studies have shown that optical detection of ultrasound can provide improved detection angle and sensitivity over significantly extended bandwidth. In this review, we provide an overview of recent technological advances in optical methods of ultrasound detection by classifying them based on their implementations in photoacoustic imaging. We further introduce a theoretical framework to generalize sensitivity, bandwidth, and spatial responses of optical ultrasound detection geometries.


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