Implantable Multi-modality Probe for Subdural Simultaneous Measurement of Electrophysiology, Hemodynamics, and Temperature Distribution
Multi-channel multi-modality measurement capabilities of near-infrared spectroscopy (NIRS), electrocorticography (ECoG), and temperature distribution were integrated into a single, flexible device compact enough for subdural implantation. Photoelectric bare chips for NIRS channels, miniature temperature-coefficient thermistors for measuring localized temperature variation, and 3-mm-diameter platinum plates for ECoG recording were assembled on a flexible printed circuit to create six channels for each modality. A conformal coating of Parylene-C was applied to make the probe surface biocompatible. The simultaneous measurement capability of the developed probe was examined, with IRB approval, in subjects during surgery and post-operative monitoring with no complications throughout the two-week implantation.
A Palm-Sized Cryoprobe System with a Built-in Thermocouple and Its Application in an Animal Model of Epilepsy
The purpose of this study is to propose a palm-sized cryoprobe system with a built-in thermocouple for highly accurate temperature measurements at the probe-tip wall. The conventional and general configuration of cryoprobe systems uses triple coaxial tubes. Moreover, in order to measure the temperature shift at the probe tip, a wired thermocouple is attached externally using adhesive. However, because the adhesive creates thermal resistance between the wired thermocouple and the external surface of the probe tip, the temperature measurement accuracy deteriorates. To cope with this problem, in this paper, we propose a cryoprobe system with a built-in thermocouple.
The Palm-Sized Cryoprobe System Based on Refrigerant Expansion and Boiling and its Application to an Animal Model of Epilepsy
The purpose of this study is to propose the palm-sized cryoprobe system based on a new concept and to suggest that the freezing technique could be used for treatment of epilepsy…