Optogenetic Excitation of Ipsilesional Sensorimotor Neurons is Protective in Acute Ischemic Stroke: a Laser Speckle Imaging Study
Specifically activating the sensorimotor neurons in acute stroke has been found to be protective. Laser speckle contrast imaging technique was used to quantify the neurovascular response to optogenetic stimulation within the first 24 hrs after stroke, in the aspect of cerebral blood flow changes. The results demonstrated that neuronal-specific excitation at acute stage could successfully compromise the expansion of the ischemic core and promote the neurovascular response after stroke. The results implied the neuron-specific modulation as a potential therapeutic intervention for the acute ischemic brain injury.