Model-Based Analysis of Electrode Placement and Pulse Amplitutde for Hippocampal Stimulation
To support advancements in memory prosthetics, we have built a computational model to study the effects of electrical stimulation on the hippocampus. Predictions made by this model were first validated against signals obtained from real tissue samples and later used to search possible electrode placements and stimulation amplitudes for combinations that elicited the most efficient tissue response.
A Million-Plus Neuron Model of the Hippocampal Dentate Gyrus: Critical Role for Topography in Determining Spatio-Temporal Network Dynamics
This work describes a million-plus granule cell compartmental model of the rat hippocampal dentate gyrus, including excitatory, perforant path input from the entorhinal cortex, and inhibitory input from dentate interneurons. Perforant path input was modeled based on axonal transport studies documenting the topographical organization of projections from subregions of the entorhinal cortex…