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Yevgeny Berdichevsky

Yevgeny Berdichevsky is with the Department of Electrical and Computer Engineering and Department of Bioengineering, Lehigh University, Bethlehem, PA, USA


Contributions

  • Epilepsy-on-a-chip System for Antiepileptic Drug Discovery
    Epilepsy-on-a-chip System for Antiepileptic Drug Discovery

    Hippocampal slice cultures spontaneously develop chronic epilepsy several days after dissection and are used as an in vitro model of post-traumatic epilepsy. This work describes the development of a hybrid microfluidic-microelectrode array device that improves the throughput of chronic recordings in hippocampal slice cultures and facilitates antiepileptic drug discovery. Our technology allows miniaturization of large and expensive multiple-slice electrophysiology systems to a single scalable chip. We used this epilepsy-on-a-chip device to carry out a screen of Receptor Tyrosine Kinases (RTKs) inhibitors and discovered two novel antiepileptic compounds. These ‘hits’ represent a promising first step in developing new antiepileptic drugs.

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