Electric Stimulus-Responsive Chitosan/MNP composite Microbeads for a Drug Delivery System
In this work, we explored a novel technique of using electric pulses as stimulus to regulate vancomycin elution profile release from a chitosan-based drug delivery substrate. Inkjet printing technology was used to print silver electrodes on an inexpensive, flexible, thin polyimide substrate. We demonstrated a significantly higher release of vancomycin from the groups that received excitation, compared to groups that did not. Such controllable drug release systems that are responsive to external stimuli will assist healthcare providers in customizing drug administration as dictated by the specific needs of each patient, thus improving overall drug efficacy.