Real-Time Photoacoustic Thermometry Combined with Clinical Ultrasound Imaging and High-Intensity Focused Ultrasound
Description: High intensity focused ultrasound (HIFU) is a non-invasive method for treating diseased tissues by locally delivering thermal and mechanical energy. In HIFU, measuring the temperature at the treatment site is important for therapeutic efficacy, safety, appropriate treatment planning. In this paper, we propose a novel integrated real-time photoacoustic thermometry system for HIFU treatment monitoring that provides real-time photoacoustic and ultrasound imaging and photoacoustic thermometry without any interference from the HIFU waves. We have successfully demonstrated the feasibility of photoacoustic thermometry with in vitro phantoms and in vivo tumor-bearing mice, which promises a safe and effective monitoring of HIFU treatment.