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Hiroshi Takamatsu


Contributions

  • Low-Voltage Irreversible Electroporation Using a Comb-Shaped Contact Electrode

    This study examined the feasibility of low-voltage contact IRE (irreversible electroporation) using a new comb-shaped miniature electrode. The electrode was designed to perforate cutaneous and subcutaneous tumor cells by touching it to the lesion surface of skin or gastrointestinal tract to apply electric pulses. Experiments using 3-D cultured cells showed that the maximum ablation depth reached 400 µm at 20 V. Insulation of lateral spaces between electrode teeth as well as administration of adjuvants to modify the cell membrane were effective and increased the ablation depth by 26% and the ablation area by 40%.

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