Avatar

Jing Liu

Jing Liu was with the Department of Electrical and Computer Engineering, Lehigh University, Bethlehem, PA, USA. She is now with University of California, San Francisco, CA, USA.


Contributions

  • Epilepsy-on-a-chip System for Antiepileptic Drug Discovery
    Epilepsy-on-a-chip System for Antiepileptic Drug Discovery

    Hippocampal slice cultures spontaneously develop chronic epilepsy several days after dissection and are used as an in vitro model of post-traumatic epilepsy. This work describes the development of a hybrid microfluidic-microelectrode array device that improves the throughput of chronic recordings in hippocampal slice cultures and facilitates antiepileptic drug discovery. Our technology allows miniaturization of large and expensive multiple-slice electrophysiology systems to a single scalable chip. We used this epilepsy-on-a-chip device to carry out a screen of Receptor Tyrosine Kinases (RTKs) inhibitors and discovered two novel antiepileptic compounds. These ‘hits’ represent a promising first step in developing new antiepileptic drugs.

Login

New Here? Sign Up

Looking for increased exposure in the field of biomedical engineering? EMBS offers journals, conferences and a community for biomedical engineers. Membership includes PULSE Magazine.

Join EMBS